The use of the antifungal agent miconazole as an inhibitor of Blastocystis hominis growth in Entamoeba histolytica/E. dispar cultures

Revista do Instituto de Medicina Tropical de São Paulo

Alessandra Queiroga Gonçalves²  João Da Costa Viana¹  Edna Maria Pires¹  Márcio Neves Bóia²  José Rodrigues Coura²  Edward Félix Silva¹ 

[1] ,Fundação Oswaldo Cruz Departamento de Medicina Tropical Laboratório de Doenças ParasitáriasRio de Janeiro RJ ,Brasil

关键词: Blastocystis hominis;    Miconazole;    Entamoeba histolytica;    Entamoeba dispar;    Culture;   

DOI  :  10.1590/S0036-46652007000300013

来源: SciELO

【 摘 要 】

In regions with high prevalence, Blastocystis hominis is frequently found in association with Entamoeba histolytica/E. dispar in xenic cultures. Its exacerbated growth is often superimposed on the growth of amebas, thus impeding the continuation of the amebas in the culture, within a few generations. The present study reports on the excellent efficacy (100%) of the antifungal agent miconazole in eliminating B. hominis from cultures of E. histolytica/E. dispar, thereby maintaining the integrity of the trophozoites of the amebas. Nystatin presented low efficacy (33.3%).

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