Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients

Revista do Instituto de Medicina Tropical de São Paulo

Luiz Sergio Azevedo¹  Maria Cristina R. Castro¹  Flavio J. Paula¹  Luiz Estevam Ianhez¹  Elias David-neto¹ 

[1] ,University of São Paulo Medical School Hospital das ClínicasSão Paulo SP ,Brazil

关键词: Kidney transplantation;    Mycophenolate mofetil;    Pneumocystis carinii;    Pneumonia;    Immunosuppression;   

DOI  :  10.1590/S0036-46652005000300005

来源: SciELO

【 摘 要 】

Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (TMS). Mycophenolate mofetil (MMF) has been shown to have a strong protective effect against PCP in rats. This effect is also suggested in humans by the absence of PCP in patients receiving MMF. After January 1998 MMF has been used with no TMS prophylaxis in renal transplanted patients. In azathioprine (AZA) treated patients TMS prophylaxis was maintained. The incidence of PCP was analyzed in both groups. Data were collected in order to have a minimum 6-month follow-up. Two hundred and seventy-two patients were eligible for analysis. No PCP occurred either in patients under MMF without TMS prophylaxis nor in patients under AZA. MMF may have an effective protective role against PCP as no patient under MMF, despite not receiving TMS coverage, developed PCP. A larger, controlled, trial is warranted to consolidate this information.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License