Seroprevalence of hepatitis B virus infection in individuals with clinical evidence of hepatitis in Goiânia, Goiás: detection of viral DNA and determination of subtypes

Revista do Instituto de Medicina Tropical de São Paulo

Claudia De Oliveira E Silva²  Marli Da Silva Pereira Azevedo²  Célia Maria De Almeida Soares¹  Regina Maria Bringel Martins²  Carmen Helena Ramos¹  Roberto Ruhman Daher²  Divina Das Dôres De Paula Cardoso² 

[1] ,Universidade Federal de Goiás Instituto de Patologia Tropical e Saúde Pública Goiânia GO ,Brasil

关键词: Hepatitis B;    HBV-DNA;    Subtypes;   

DOI  :  10.1590/S0036-46652002000600007

来源: SciELO

【 摘 要 】

The presence of serological markers for hepatitis B virus (HBsAg, anti-HBc IgM and Anti-HBc total) was investigated in the serum of 1,396 individuals who had clinical suspect of hepatitis. It was observed that 50.7% of the individuals were positive and, from the total of the studied individuals, 14.5% were positive for HBsAg. From these, 8.5% were also positive for anti-HBc IgM. The analysis in relation to gender showed a higher seroprevalence index among male individuals (p < 0.0001). It was observed the occurrence of subtypes adw2 (62.7%), ayw3 (23.5%), ayw2 (9.8%) and adw4 (3.9%). The viral DNA was detected in 61 (33.9%) HBsAg positive samples and in one sample positive only for anti-HBc total. These results indicate an important incidence of the HBV infection in this population, and reinforce previous studies regarding this virus in the central west region of Brazil.

【 授权许可】

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