Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae)

Revista do Instituto de Medicina Tropical de São Paulo

Lucienir Pains Duarte²  Sidney Augusto Vieira Filho²  Grácia Divina De Fátima Silva²  José Rego De Sousa²  Artur Da Silveira Pinto¹ 

[1] ,UFMG Departamento de Química Núcleo de Estudo de Plantas Medicinais MG ,Brasil

关键词: Austroplenckia populnea;    Pentacyclic triterpenes;    Anti-trypanosomal activity;    Growth inhibition;   

DOI  :  10.1590/S0036-46652002000200010

来源: SciELO

【 摘 要 】

Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less active, while populnilic and populninic acids were inactive against the trypanosome of the subgenus Schizotrypanum tested. Benzonidazole, nifurtimox, ketoconazole and primaquine presented a remarkable dose-dependent inhibitory effect reaching practically to a total growth inhibition of the parasite at the end of incubation time. The trypanosome tested appear to be a suitable model for preliminary screen for anti T. (S.) cruzi compounds.

【 授权许可】

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