In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence

Revista do Instituto de Medicina Tropical de São Paulo

Carla M. S. Menezes¹  Karin Kirchgatter²  Sílvia M. F. Di Santi²  Carine Savalli²  Fabíola G. Monteiro²  Gilberto A. Paula²  Elizabeth I. Ferreira¹ 

[1] ,Universidade de São PauloSão Paulo SP ,Brasil

关键词: Erythromycin;    Modulating effect;    Antimalarial activity;    Chloroquine P. falciparum resistance;   

DOI  :  10.1590/S0036-46651999000400009

来源: SciELO

【 摘 要 】

Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.

【 授权许可】

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