Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: II. Corynebacterium parvum

Revista do Instituto de Medicina Tropical de São Paulo

Kirte M Teixeira²  Eridan M Coutinho¹  Frederico G.c. Abath¹  Silvia M.l. Montenegro¹ 

[1] ,FIOCRUZ Centro de Pesquisas Aggeu Magalhães Departamento de ImunologiaRecife PE ,Brasil

关键词: Corynebacterium parvum;    Schistosoma mansoni;    Immunopotentiators;    Chemotaxis;   

DOI  :  10.1590/S0036-46651996000500007

来源: SciELO

【 摘 要 】

The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed.

【 授权许可】

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