Cardiac sympathetic-parasympathetic balance in rats with experimentally-induced acute chagasic myocarditis

Revista do Instituto de Medicina Tropical de São Paulo

Diego F. Davila¹  Carlos F. Gotterberg¹  Argenis Torres¹  Geza Holzhaker¹  Richard Barrios¹  Paolo Ramoni¹  José H. Donis¹ 

关键词: Myocarditis;    Chagas disease;    Cardiac Autonomic System;    Atropine;    Beta-Blockers;   

DOI  :  10.1590/S0036-46651995000200011

来源: SciELO

【 摘 要 】

To clarify the mechanism responsible for the transient sinus tachycardia in rats with acute chagasic myocarditis, we have examined the cardiac sympathetic-parasympathetic balance of 29 rats inoculated with 200,000 parasites (Trypanosoma cruzi). Sixteen infected animals and 8 controls were studied between days 18 and 21 after inoculation (acute stage). The remaining 13 infected animals and 9 controls were studied between days 60 and 70 after inoculation (sub-acute stage). Under anesthesia (urethane 1.25 g/kg), all animals received intravenous atenolol (5 mg/kg) and atropine (10 mg/kg). Acute stage: The baseline heart rate of the infected animals was significantly higher than that of the controls (P < 0.0001). The magnitude of the negative chronotropic response to atenolol was 4 times that of the controls (P < 0.00001). This response correlated with the baseline heart rate (r= - 0.72, P < 0.001). The heart rate responses to the beta-blocker and to atropine, of the infected animals studied during the sub-acute stage, were not different from controls. These findings suggest that cardiac sympathetic activity is transiently enhanced and cardiac parasympathetic activity is not impaired, in rats with acute chagasic myocarditis. The transient predominance of cardiac sympathetic activity could explain, in part, the sinus tachycardia observed in the acute stage of experimentally-induced chagasic myocarditis.

【 授权许可】

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