Schistosoma mansoni: the effect of dexamethasone on the cercaria-schistosomulum transformation, in vivo

Revista do Instituto de Medicina Tropical de São Paulo

Alan Laue De Melo¹  Marco Victor Hermeto¹  Rosilene Siray Bicalho¹  Antônio Pedro Vargas¹  Fábio Júnior Oliveira Favaretto¹  Leógeues Horácio Pereira¹ 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Departamento de ParasitologiaBelo Horizonte MG ,Brasil

关键词: Schistosoma mansoni;    Peritoneal cavity;    Dexamethasone;    Neutrophil;    Cercaria;    Schistosomulun;   

DOI  :  10.1590/S0036-46651994000100014

来源: SciELO

【 摘 要 】

Treatment with dexamethasone (DMS) in the early phases of the experimental Schistosoma mansoni infection causes an indirect effect on the cercaria-schistosomulum transformation process. This is observed when naive albino mice are treated with that drug (50 mg/Kg, subcutaneously) and infected intraperitonealy 01 hour later with about 500 S. mansoni cercariae (LE strain). An inhibition in the host cell adhesion to the larvae, with a simultaneous delay in the cercaria-schistosomulum transformation, is observed. This effect is probably due to a blockade of the neutrophil migration to the peritoneal cavity of mice, by an impairment of the release of chemotactic substances. Such delay probably favors the killing of S. mansoni larvae, still in the transformation process, by the vertebrate host defenses, as the complement system.

【 授权许可】

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