Schistosoma mansoni: protective immunity in mice cured by chemotherapy at the chronic phase of the disease

Revista do Instituto de Medicina Tropical de São Paulo

Fernando Schemelzer De Moraes Bezerra²  Paulo Marcos Zech Coelho¹  Carlos Alberto Pereira Tavares¹ 

[1] ,Universidade Federal do Ceará Centro de Ciências da Saúde Departamento de Análises Clínicas e ToxicológicasFortaleza CE ,Brasil

关键词: Schistosoma mansoni;    Chemotherapy;    Residual immunity;    Concomitant immunity;   

DOI  :  10.1590/S0036-46651993000400006

来源: SciELO

【 摘 要 】

Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery of worms at 20 days after reinfections showed that a residual immunity remains up to 90 days after treatment, and disappears at 170 days after cure. Using the ELISA method, it was possible to detect a decrease of antibody levels (total IgG) in the treated group, when antigens from different evolutive stages of S. mansoni were used. The epidemiological implications of the present results, and the possible mechanisms involved in the decrease of acquired immunity after treatment are discussed.

【 授权许可】

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