Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni

Revista do Instituto de Medicina Tropical de São Paulo

Ana Lúcia Teles Rabello²  Roberto Sena Rocha²  João Paulo Mendes De Oliveira¹  Naftale Katz²  José Roberto Lambertucci¹ 

[1],Fundação Oswaldo Cruz Centro de Pesquisas René Rachou ,Brasil

关键词: Schistosoma mansoni;    Stool examination;    Egg counts;    Rectal biopsy;    Oxamniquine;   

DOI  :  10.1590/S0036-46651992000600016

来源: SciELO

【 摘 要 】

From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods.

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