Experimental coccidioidomycosis in the immunosuppressed rat

Revista do Instituto de Medicina Tropical de São Paulo

Mirta C. Remesar¹  Jorgelina L. Blejer¹  Ricardo Negroni¹  Marta R. Nejamkis¹ 

[1] ,Buenos Aires University Faculty of Medicine Department of Microbiology,Argentina

关键词: Rat;    Coccidioidomycosis;    Cyclophosphamide;    Immunosuppression;    T suppressor cells;    Reactivation;   

DOI  :  10.1590/S0036-46651992000400006

来源: SciELO

【 摘 要 】

C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection.

【 授权许可】

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