Experimental life cycle of Lagochilascaris minor Leiper, 1909

Revista do Instituto de Medicina Tropical de São Paulo

Dulcinéa Maria Barbosa Campos¹  Lindomar G. Freire Filha²  Miguel Alípio Vieira¹  Julieta Machado Paçô¹  Moacir A. Maia¹ 

[1] ,UFG IPTESP Parasitology Department

关键词: Lagochilascaris minor;    Experimental life cycle;    Transmission mechanisms;   

DOI  :  10.1590/S0036-46651992000400003

来源: SciELO

【 摘 要 】

The life cycle of Lagochilascaris minor was studied using material collected from human lesion and applying the experimental model: rodents (mice, hamsters), and carnivorae (cats, dogs). In mice given infective eggs, orally, hatch of the third stage larvae was noted in the gut wall, with migration to liver, lungs, skeletal musculature and subcutaneous tissue becoming, soon after, encysted. In cats infected with skinned carcasses of mice (60 to 235 days of infection) it was observed: hatch of third stage larvae from the nodules (cysts) in the stomach, migration through the oesophagus, pharynx, trachea, related tissues (rhino-oropharynx), and cervical lymphonodes developing to the mature stage in any of these sites on days 9-20 post inoculation (P.I.). There was no parasite development up to the mature stage in cats inoculated orally with infective eggs, which indicates that the life cycle of this parasite includes an obligatory intermediate host. In one of the cats (fed carcass of infected mice) necropsied on day 43 P.I., it was observed the occurence of the self-infective cycle of L. minor in the lung tissues and in the cervical region which was characterized by the finding of eggs in different stages of development, third stage larvae and mature worms. It's believed that some component of the carnivorae gastrointestinal tracts may preclude the development of third stage larvae from L. minor eggs what explains the interruption of the life cycle in animals fed infective eggs. It's also pointed out the role of the intermediate host in the first stages of the life cycle of this helminth.

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