期刊论文详细信息
Revista do Instituto de Medicina Tropical de São Paulo
Paracoccidioidomycosis: a sequential histopathologic study of lesions in experimentally-infected rats
I.b. Kerr2  J.r. Araripe2  P.c. Oliveira1  H.l. Lenzi2 
[1] ,Fundação Oswaldo Cruz Instituto Oswaldo Cruz Department of PathologyRio de Janeiro RJ ,Brazil
关键词: Paracoccidioidomycosis;    Paracoccidioides brasiliensis;    Granuloma;    Extracellular matrix;    Collagen;    Proteoglycans;   
DOI  :  10.1590/S0036-46651988000500003
来源: SciELO
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【 摘 要 】

Female albino rats were used for the sequential histopathological study of experimental paracoccidioidomycosis. The animals were inoculated intraperitoneally with a strain of Paracoccidioides brasiliensis in the yeast-like phase, and sacrificed at given intervals from 1 to 168 days after inoculation; each animal received an inoculum of 4 x 10(6) cells in 0.8 ml of saline. The control group received saline containing scrapings of the culture medium. Tissue from the inoculation site was examined. The cellular population, the extracellular matrix, and the presence and characteristics of fungi were analysed in the inflammatory granulomatous process by light microscopy. The results allowed to separate the kinetic of the inflammatory response into three stages: 1) neutrophilic or macrophagic-neutrophilic; 2) pre-granulomatous; 3) granulomatous. Synthesis of the extracellular matrix began with the depositing of fibrin-like material, and increased gradually with deposits of collagen, proteoglycans, and glycoproteins. Parasites were present in all of the examined periods. Recurrences of the disease were clearly shown through the concurrence of recently-formed granulomas with older granulomas, implying that this type of granulomatous process does not eliminate the disease, nor is it able to limit fungal dissemination over a prolonged period of time.

【 授权许可】

CC BY-NC   
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