Failure at inducing resistance to schistosomicidal drugs in a Brazilian human strain of Schistosoma mansoni

Revista do Instituto de Medicina Tropical de São Paulo

Luiz Candido De Souza Dias²  Celso Eduardo Olivier¹ 

[1] ,Universidad Estadual de Campinas Departamento de Parasitologia Campinas S. Paulo ,Brasil

关键词: Schistosomiasis;    Schistosoma mansoni;   

DOI  :  10.1590/S0036-46651986000500010

来源: SciELO

【 摘 要 】

In this work, an attempt was made to induceng resistance to 3 schistosomicidal drugs in a Brazilian strain of S. mansoni, according to the Type II resistance induction scheme proposed by JANSMA et al. in 1977. Three attempts were unsuccessful. The parental generation treated with the drug during the immature stage of the worm was less susceptible to the chemotherapeutic agents than generations F1 and F2. A hypothesis is suggested as an explanation.

【 授权许可】

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