Changes of rabbit pulmonary elastic properties and bronchomotrlclty in experimentally induced chronic Chagas' disease

Revista do Instituto de Medicina Tropical de São Paulo

Paulo Tavares²  Paulo Hilário Nascimento Saldiva¹  Marina Pires Do Rio Caldeira¹  Débora Fernandes Calheiros¹  Maria Alice Gouveia¹  Carmen Diva Saldiva¹ 

[1] ,UNB Faculdade de Ciencias da Saúde

关键词: Experimental trypanosomiasis;    Rabbit;    Changes in pulmonary;    Elastic properties;   

DOI  :  10.1590/S0036-46651986000500007

来源: SciELO

【 摘 要 】

In order to study the role of bronchial denervation in Chagas' disease, the mechanical properties and the hronchomotricity o£ 6 chronic chagasic and 4 control rabbits were investigated. The whole-body plethysmograph method was used and the measurements were performed before and after intravenous administration of histamine chlorhydrate (0.11 mg/kg body weight). A smaller increase of the functional residual capacity, an almost unchanged peak passive expiratory flow after the histamine administration and a shift to the right of the static transpulmonary pressure/volume curve observed in the chagasic animals indicate an alteration of the bronchial tree, mainly consisting of a decreased bronehoreactivity.

【 授权许可】

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