Strongyloses ratti and S. stercoralis: effects of cambendazole, thiabendazole and mebendazole in vitro

Revista do Instituto de Medicina Tropical de São Paulo

David I. Grove¹  Carolyn Northern¹ 

[1] ,University of Western Australia Department of Medicine Queen Elizabeth It Medical CentreNeulands Western Australia

关键词: Strongyloides ratti;    Strongyloides stercoralis;    Action in vitro drugs;    Cambendazole;    Thiabendazole;    Mebendazole;   

DOI  :  10.1590/S0036-46651986000200006

来源: SciELO

【 摘 要 】

The effects of in vitro incubation of three henzimidazole anthelmintics, thiabendazole, mebendazole and cambendazole on Strongyloides were compared. No drug affected hatching of S. ratti eggs or the viability of infective larvae or parasitic adult worms, but all three inhibited moulting of S. ratti larvae. In addition, cambendazole, but not thiabendazole or mebendazole, impaired the viability of S. ratti first- and second-stage larvae. The three drugs had no effect on isolated S. stercorais free-living adult worms, but they all prevented development of S. stercoralis rhabditiform larvae. Thiabendazole and mebendazole had no effect on the infectivity of either S. ratti or S. stercoralis infective larvae, but infection with these worms was abrogated by prior incubation with cambendazole. These results indicate that cambendazole acts in a different manner to the other two drugs. Since it is active against larvae migrating through the tissues, it is potentially of much greater value than thiabendazole or mebendazole in the therapy of strongyloidiasis.

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