Retreatment in leprosy: a case-control study

Revista de Saúde Pública

Ricardo Arraes Alencar Ximenes²  Maria Eugênia Novinsk Gallo¹  Maria De Fátima De Medeiros Brito¹ 

[1] ,Universidade Federal de Pernambuco Centro de Ciências da Saúde Departamento de Medicina TropicalRecife PE ,Brasil

关键词: Leprosy;    Leprosy;    Leprostatic agents;    Treatment outcome;    Recurrence;    Case-control studies;    Hanseníase;    Hanseníase;    Hansenostáticos;    Resultado de tratamento;    Recidiva;    Estudos de casos e controles;   

DOI  :  10.1590/S0034-89102006005000037

来源: SciELO

【 摘 要 】

OBJECTIVE: To assess risk factors for retreatment of leprosy patients. METHODS: A case-control study with patients from two reference care units in Recife, northeastern Brazil, in 2003. The case group included retreated patients (N=155) and the control group comprised those patients who were not retreated (N=155) matched by year of diagnosis and health care unit. Univariate and multivariate analyses were conducted to test the associations and odds ratios and related 95% confidence intervals were estimated. RESULTS: The following factors were found to be significantly associated (p<0.05) with retreatment: occurrence of adverse immunological reactions after treatment completion (OR=2.3; 95% CI=1.18;4.83), final bacterial index > 1 (OR=6.43; 95% CI=1.67;24.74), therapeutic regimen consisting of sulfone monotherapy (OR=10; 95% CI=0.01;0.78) and reports of household contacts (OR=2.2; 95% CI=0.24;0.85). CONCLUSIONS: The study findings reinforce that the use of dapsone monotherapy should be discontinued, and highlight the need for epidemiological monitoring of specific groups of leprosy patients after treatment completion through periodical clinical and laboratory evaluation. Further studies to explore the association between final bacterial index and retreatment are strongly recommended.

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