Malaria transmission model for different levels of acquired immunity and temperature-dependent parameters (vector)

Revista de Saúde Pública

Hyun M Yang¹ 

[1] ,Universidade Estadual de Campinas Instituto de Matemática, Estatística e Ciência da Computação Departamento de Matemática AplicadaCampinas SP ,Brasil

关键词: Malaria transmission;    Epidemiologic models;    Anopheles;    Plasmodium;    Host parasitic relations;    Insect vectors;    Malária;    Modelos epidemiológicos;    Anopheles;    Plasmodium;    Relações hospedeiro-parasita;    Insetos vetores;   

DOI  :  10.1590/S0034-89102000000300003

来源: SciELO

【 摘 要 】

OBJECTIVE: Describe the overall transmission of malaria through a compartmental model, considering the human host and mosquito vector. METHODS: A mathematical model was developed based on the following parameters: human host immunity, assuming the existence of acquired immunity and immunological memory, which boosts the protective response upon reinfection; mosquito vector, taking into account that the average period of development from egg to adult mosquito and the extrinsic incubation period of parasites (transformation of infected but non-infectious mosquitoes into infectious mosquitoes) are dependent on the ambient temperature. RESULTS: The steady state equilibrium values obtained with the model allowed the calculation of the basic reproduction ratio in terms of the model's parameters. CONCLUSIONS: The model allowed the calculation of the basic reproduction ratio, one of the most important epidemiological variables.

【 授权许可】

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