Composite synthetic hydroxyapatite 30%, in two physical states, as dermal filler

Revista Ceres

Rodrigo Viana Sepúlveda²  Andréa Pacheco Batista Borges¹  Lissandro Gonçalves Conceição¹  Fabrício Luciani Valente¹  Emily Correna Carlo Reis¹  Ingrid Bitencourt Bohnenberger² 

[1] ,Universidade Federal de Viçosa Departamento de Veterinária Viçosa Minas Gerais ,Brazil

关键词: cutaneous implant;    composite;    aesthetic medicine;    implante cutâneo;    compósito;    medicina estética;   

DOI  :  10.1590/S0034-737X2013000400003

来源: SciELO

【 摘 要 】

The aim of this study was to evaluate the response to the implantation of synthetic hydroxyapatite 30% (HAP-91®) in different physical states as dermal filler. Eighteen New Zealand rabbits were used, distributed randomly into two equal groups and then divided into three groups according to the postoperative period at 8, 21 and 49 days. One mL of HAP-91®, fluid and viscous, was implanted in the subcutaneous tissue, 1 cm proximal to the cranial crest of the right scapula. The thickness of the skin was measured before and after implantation and for the following 15 days. Pain sensitivity assessment was conducted, assigning the following scores: 0 - when the animal allowed the touch of the implant area and expressed no signs of pain; 1 - when the animal allowed the touch, but pain reaction occurred, like increase of the respiratory rate or attempt to escape; 2 - when the animal did not allow the touch to the implanted area. At 8, 21 and 49 days, biopsy of the implanted area was performed. No difference was observed between the thickness of the skin (p>0.05) and all animals received a score 0 for soreness. Histological analysis did not reveal any obvious inflammatory process, showing a predominance of mononuclear cells in samples of eight days and tissue organization around the biomaterial with a tendency to encapsulation. The results indicate that HAP-91®, both viscous and fluid, is biocompatible and suitable for dermal filling.

【 授权许可】

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