Importance of genetic polymorphisms in the response to age-related macular degeneration treatment

Revista Brasileira de Oftalmologia

Carlos Eduardo Dos Reis Veloso²  Luciana Negrão Frota De Almeida²  Luiz Armando De Marco¹  Raul Nunes Galvarro Vianna¹  Márcio Bittar Nehemy¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de OftalmologiaBelo Horizonte MG ,Brasil

关键词: Macular degeneration;    Antioxidants;    Polymorphism;    Treatment outcome;    Degeneração macular;    Antioxidantes;    Polimorfismo genético;    Resultado de tratamento;   

DOI  :  10.1590/S0034-72802012000300011

来源: SciELO

【 摘 要 】

Age-related macular degeneration (AMD) is a degenerative disorder that affects the central retina and involves the Bruch's membrane, the retinal pigment epithelium and the photoreceptors. Recent studies have shown that polymorphisms of the CFH, LOC387715 and VEGF genes are associated with AMD. Herein, we review the literature to analyze the association between the main genetic polymorphisms and the response to the existing therapeutic modalities. Patients with CFH high-risk alleles show a poorer response to preventive treatment of AMD with antioxidants and zinc.The association between genetic polymorphisms and response to photodynamic therapy and antiangiogenic drugs, however, is controversial until now.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License