Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus

Revista Brasileira de Anestesiologia

Fabio Ferreira Da Cunha Brião¹  Marcio Leal Horta¹  Bernardo Lessa Horta¹  Guilherme Antônio Moreira De Barros¹  Ana Paula Behrensdorf¹  Ingrid Severo¹  Mariana Antunes Nunes¹  Roberta Boabaid¹  André Real¹ 

关键词: Droperidol;    Morphine;    Ondansetron;    Pruritus;    Subarachnoid injection;    Droperidol;    Morfina;    Ondansetron;    Prurido;    Injeção subaracnoidea;    Droperidol;    Morfina;    Ondansetrón;    Prurito;    Inyección subaracnoidea;   

DOI  :  10.1016/j.bjane.2013.11.005

来源: SciELO

【 摘 要 】

The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus. 180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2 mg were randomized to receive, after the child's birth, metoclopramide 10 mg (Group I - control), droperidol 2.5 mg (Group II) or ondansetron 8 mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined. Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively. Ondansetron does not inhibit subarachnoid morphine-induced pruritus.

【 授权许可】

CC BY-NC-ND   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License