Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy

Revista Brasileira de Anestesiologia

Caio Marcio Barros De Oliveira¹  Rioko Kimiko Sakata¹  Alexandre Slullitel¹  Reinaldo Salomão¹  Vera Lucia Lanchote¹  Adriana Machado Issy¹ 

关键词: Lidocaine;    Intravenously;    Postoperative pain;    Hysterectomy;    Interleukin-6;    Lidocaína;    Via venosa;    Dor pós-operatória;    Histerectomia;    Interleucina-6;    Lidocaína;    Vía venosa;    Dolor postoperatorio;    Histerectomía;    Interleucina-6;   

DOI  :  10.1016/j.bjane.2013.07.017

来源: SciELO

【 摘 要 】

BACKGROUND AND OBJECTIVES: Interleukin-6 is a predictor of trauma severity. The purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma interleukin-6 after hysterectomy. METHOD: A prospective, randomized, comparative, double-blind study with 40 patients, aged 18-60 years. G1 received lidocaine (2 mg kg-1 h-1) or G2 received 0.9% saline solution during the operation. Anesthesia was induced with O2/isoflurane. Pain severity (T0: awake and 6, 12, 18 and 24 h), first analgesic request, and dose of morphine in 24 h were evaluated. Interleukin-6 was measured before starting surgery (T0), 5 h after the start (T5), and 24 h after the end of surgery (T24). RESULTS: There was no difference in pain severity between groups. There was a decrease in pain severity between T0 and other measurement times in G1. Time to first supplementation was greater in G2 (76.0 ± 104.4 min) than in G1 (26.7 ± 23.3 min). There was no difference in supplemental dose of morphine between G1 (23.5 ± 12.6 mg) and G2 (18.7 ± 11.3 mg). There were increased concentrations of IL-6 in both groups from T0 to T5 and T24. There was no difference in IL-6 dosage between groups. Lidocaine concentration was 856.5 ± 364.1 ng mL-1 in T5 and 30.1 ± 14.2 ng mL-1 in T24. CONCLUSION: Intravenous lidocaine (2 mg kg-1 h-1) did not reduce pain severity and plasma levels of IL-6 in patients undergoing abdominal hysterectomy.

【 授权许可】

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