Cortical spreading depression in migraine-time to reconsider?

Arquivos de Neuro-Psiquiatria

Alan J Mccomas¹  Adrian R M Upton¹ 

关键词: migraine;    spreading depression;    transcranial magnetic stimulation;    enxaqueca;    depressão alastrante;    estimulação magnética transcraniana;   

DOI  :  10.1590/0004-282X20150094

来源: SciELO

【 摘 要 】

New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of other observations, make it unlikely that cortical spreading depression is involved in migraine. tTMS is considered to act by abolishing abnormal impulse activity in cortical pyramidal neurons and a suggestion is made as to how this activity could arise.

【 授权许可】

CC BY   
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