期刊论文详细信息
Arquivos de Neuro-Psiquiatria
Relative luminosity in the plus maze upon the exploratory behaviour of female Wistar rats
Diana Yae Sakae1  Thiago Mamoru Sakae1  Marta Aparecida Paschoalini1  Moacir Serralvo Faria1 
关键词: estrous cycle;    female;    Wistar rats;    anxiety;    fear;    elevated plus-maze;    luminosity;    ciclo estral;    ratas Wistar;    ansiedade;    medo;    labirinto elevado em cruz;    luminosidade;   
DOI  :  10.1590/0004-282X20150088
来源: SciELO
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【 摘 要 】

Objective This study evaluated the provision of two configuration of the Elevated Pluz-Maze (EPM) by analizing the exploratory behaviour of female Wistar rats in different phases of the estrous cycle in EPMs with different gradients of luminosity between the open and enclosed arms (O/E∆Lux).Methods Female Wistar rats were treated with Midazolam (MDZ, 1.0 mg.kg-1) and were tested for their exploratory behaviour in either the EPM 10 O/E∆Lux or EPM 96 O/E∆Lux.Results A multiple regression analysis indicated that the O/E∆Lux is negatively associated with the %Open arm entries and %Open arm time, suggesting that as O/E∆Lux increases, the open arm exploration decreases. The estrous cycle phase did not influence the open-arm exploration in either EPM. MDZ- induced anxiolysis was detected in 96 O/E∆Lux EPM in all phases of the EC.Discussion Results of this study suggest the importance of the O/E∆Lux to establish the arm preference in the EPM, and to preserve the predictive validity of the EPM.

【 授权许可】

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