Auditory P300 Event-Related Potentials in Children with Sydenham?s Chorea

Arquivos de Neuro-Psiquiatria

Hasan Hüseyin Ozdemir¹  Kaan Demiroren¹  Caner F. Demir¹  Mine Hapsen Serin¹ 

关键词: Sydenham?s chorea;    cognitive function;    event-related potentials;    Coreia de Sydenham;    função cognitiva;    potenciais evento-relacionados;   

DOI  :  10.1590/0004-282X20140099

来源: SciELO

【 摘 要 】

P300 event-related potentials (ERPs), objective measures related to cognitive processing, have not been studied in Sydenham’s chorea (SC) patients.Purpose:To assess cognitive impairment with P300 ERPs. Method:Seventeen patients with SC and 20 unaffected healthy children were included. Stanford–Binet test was used for psychometric assessment, and odd-ball paradigm was used for auditory ERPs. Results:There was no significant difference in P300 latencies between the SC-pretreatment group, SC-posttreatment group and control group (p>0.05). Mean interpeak latencies in SC-pretreatment group and SC-posttreatment group showed significant prolongation compared with the control group (p<0.05). Mean interpeak latencies in SC-posttreatment group were significantly decreased compared with SC-pretreatment group (p<0.05). Compared to controls, patients did not show significant difference in Stanford-Binet intelligence examination. Conclusion:This report suggests that interpeak latencies and amplitudes of P300 ERPs could be useful for detecting and monitoring cognitive impairment in SC patients.

【 授权许可】

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