Treadmill training as an augmentation treatment for Alzheimer?s disease: a pilot randomized controlled study

Arquivos de Neuro-Psiquiatria

Cynthia Arcoverde¹  Andrea Deslandes¹  Helena Moraes¹  Cloyra Almeida¹  Narahyana Bom De Araujo¹  Paulo Eduardo Vasques¹  Heitor Silveira¹  Jerson Laks¹ 

关键词: Alzheimer?s disease;    aerobic exercise;    physical training;    cognitive function;    functional capacity;    doença de Alzheimer;    exercício aeróbio;    treinamento físico;    função cognitiva;    capacidade funcional;   

DOI  :  10.1590/0004-282X20130231

来源: SciELO

【 摘 要 】

Objective To assess the effect of aerobic exercise on the cognition and functional capacity in Alzheimer’s disease (AD) patients. Method Elderly (n=20) with mild dementia (NINCDS-ADRDA/CDR1) were randomly assigned to an exercise group (EG) on a treadmill (30 minutes, twice a week and moderate intensity of 60% VO2max) and control group (GC) 10 patients. The primary outcome measure was the cognitive function using Cambridge Cognitive Examination (CAMCOG). Specifics instruments were also applied to evaluate executive function, memory, attention and concentration, cognitive flexibility, inhibitory control and functional capacity. Results After 16 weeks, the EG showed improvement in cognition CAMCOG whereas the CG declined. Compared to the CG, the EG presented significant improvement on the functional capacity. The analysis of the effect size has shown a favorable response to the physical exercise in all dependent variables. Conclusion Walking on treadmill may be recommended as an augmentation treatment for patients with AD.

【 授权许可】

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