Antiparasitic antibodies occur with similar frequency in patients with clinically established multiple sclerosis with or without oligoclonal bands in the cerebrospinal fluid

Arquivos de Neuro-Psiquiatria

Fabiana Cruz Gomes Da Fonseca-papavero²  Dagoberto Callegaro¹  Paulo Diniz Da Gama¹  Jose Antonio Livramento²  Adelaide Jose Vaz¹  Luis Dos Ramos Machado¹ 

[1] ,USP FM Laboratorio de Investigacao Medica em NeurologiaSao Paulo SP ,Brazil

关键词: hygiene hypothesis;    multiple sclerosis;    oligoclonal bands;    Taenia antigens;    antiparasitic antibodies;    hipotese da higiene;    esclerose multipla;    bandas oligoclonais;    antígenos de Taenia;    anticorpos antiparasitarios;   

DOI  :  10.1590/0004-282X20130079

来源: SciELO

【 摘 要 】

The "hygiene hypothesis" postulates an inverse relationship between the prevalence of parasitic infections and the frequency of multiple sclerosis (MS). Objective: It was to study whether antibodies against parasites could be demonstrated more frequently in blood serum from MS patients with oligoclonal bands (OCB) than from MS patients without OCB. Methods: We studied serum samples from 164 patients who had previously been analyzed to investigate OCB. Parasitic antibodies were studied through unidimensional electrophoresis of proteins on polyacrylamide gel against Taenia antigens, searching for antiparasitic specific low molecular weight antibodies and also for antiparasitic nonspecific high molecular weight antibodies. Results: Two of the 103 patients with no evidence of OCB had antibodies of low molecular weight and 59 of them had antibodies of high molecular weight. Of the 61 patients with evidence of OCB, one showed antibodies of low molecular weight and 16 showed antibodies of high molecular weight. Conclusion: Antiparasitic antibodies are detected with similar frequency in MS patients with OCB and in MS patients without OCB.

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