Primary neural leprosy: systematic review

Arquivos de Neuro-Psiquiatria

Jose Antonio Garbino¹  Wilson Marques Jr¹  Jaison Antonio Barreto¹  Carlos Otto Heise¹  Marcia Maria Jardim Rodrigues¹  Sergio L. Antunes¹  Cleverson Teixeira Soares¹  Marcos Cesar Floriano¹  Jose Augusto Nery¹  Maria Angela Bianconcini Trindade¹  Noemia Barbosa Carvalho¹  Nathalia Carvalho De Andrada¹  Amilton Antunes Barreira¹  Marcos Da Cunha Lopes Virmond¹ 

关键词: leprosy;    neuropathy;    systematic review;    diagnosis;    hanseniase;    neuropatia;    revisao sistematica;    diagnostico;   

DOI  :  10.1590/0004-282X20130046

来源: SciELO

【 摘 要 】

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

【 授权许可】

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