Availability of olfactory bulb: experience from a British Brain Bank

Arquivos de Neuro-Psiquiatria

Suraj Rajan²  Linda Parsons¹  Andrew J Lees¹  Laura Silveira-moriyama¹ 

[1] ,UCL Institute of Neurology London,UK

关键词: olfactory bulb;    olfactory tract;    brain bank;    autopsy;    Parkinson's disease;    bulbo olfatório;    trato olfatório;    banco de cérebro;    autópsia;    doença de Parkinson;   

DOI  :  10.1590/S0004-282X2013005000005

来源: SciELO

【 摘 要 】

The olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions. The availability of OB/OT samples from brain specimens in brain banks therefore assumes importance. We collected data from 5 years (2006-2010) regarding the presence or absence of OB/OT material in cases received by the Queen Square Brain Bank (QSBB) for Neurological Disorders, UCL Institute of Neurology, UK, to estimate availability of OB/OT material at the brain bank and also to look for possible associations. Of the 438 cases received, 320 had complete data regarding OB/OT and 29.4% of these had OB/OT in at least one half of the specimen. Unavailability of OB/OT was associated with larger post-mortem delays (p<0.001), suggesting that the delay might render the tissue more friable and hence lead to its loss. Brains from female donors also tended to have a higher availability in our samples.

【 授权许可】

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