Cognitive impairment is correlated with reduced quality of life in patients with clinically isolated syndrome

Arquivos de Neuro-Psiquiatria

Carolina Fiorin Anhoque²  Laurentino Biccas-neto¹  Simone Cristina A. Domingues¹  Antônio Lúcio Teixeira¹  Renan Barros Domingues¹ 

[1] ,Federal University of Minas Gerais Neuroscience Post-graduation Program Belo Horizonte MG ,Brazil

关键词: clinically isolated syndrome;    quality of life;    cognition;    depression;    anxiety;    síndrome clinicamente isolada;    qualidade de vida;    cognição;    depressão;    ansiedade;   

DOI  :  10.1590/S0004-282X2013005000004

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the quality of life (QoL) and potential QoL determinants in patients with clinically isolated syndrome (CIS). METHODS: Eighteen CIS patients and eighteen controls were submitted to QoL evaluation with Functional Assessment of Multiple Sclerosis QoL instrument (FAMS). Cognition was evaluated with specific battery tests; Anxiety and depression with Beck Anxiety (BAI) and Depression (BDI) Inventories and Neurological disability with Guy's Neurological Disability Scale (GNDS). RESULTS: There was a significant difference in QoL between CIS patients and controls. CIS patients had worse performance in Paced Auditory Serial Addition 2 seconds (p=0.009) and fluency tests (p=0.0038). There was a significant difference in BAI (p=0.003), but no significant difference in BDI between patients and controls. There were significant correlations between QoL measure and verbal fluency and Stroop's test. CONCLUSIONS: Cognition, but not anxiety, depression and disability, was associated with reduced quality of life.

【 授权许可】

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