What do we know about the neurogenic potential of different stem cell types?

Arquivos de Neuro-Psiquiatria

Guilherme Lepski¹ 

[1] ,Eberhard Karls University Department of Neurosurgery Tübingen,Germany

关键词: fetal neuronal stem cells;    embryonic stem cells;    induced pluripotent stem cells;    electrophysiology;    neuronal differentiation;    células-tronco neuronais fetais;    células-tronco embrionárias;    células-tronco pluripotentes induzidas;    eletrofisiologia;    diferenciação neuronal;   

DOI  :  10.1590/S0004-282X2012000700013

来源: SciELO

【 摘 要 】

Cell therapies, based on transplantation of immature cells, are being considered as a promising tool in the treatment of neurological disorders. Many efforts are being concentrated on the development of safe and effective stem cell lines. Nevertheless, the neurogenic potential of some cell lines, i.e., the ability to generate mature neurons either in vitro or in vivo, is largely unknown. Recent evidence indicate that this potential might be distinct among different cell lines, therefore limiting their broad use as replacement cells in the central nervous system. Here, we have reviewed the latest advancements regarding the electrophysiological maturation of stem cells, focusing our attention on fetal-derived-, embryonic-, and induced pluripotent stem cells. In summary, a large body of evidence supports the biological safety, high neurogenic potential, and in some diseases probable clinical efficiency related to fetal-derived cells. By contrast, reliable data regarding embryonic and induced pluripotent stem cells are still missing.

【 授权许可】

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