Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder

Arquivos de Neuro-Psiquiatria

Carolina Cappi²  Renan Kawano Muniz²  Aline Santos Sampaio²  Quirino Cordeiro¹  Helena Brentani²  Selma A. Palácios¹  Andrea H. Marques²  Homero Vallada²  Eurípedes Constantino Miguel²  Luiza Guilherme¹  Ana Gabriela Hounie² 

[1] ,University of São Paulo Medical School Department and Institute of PsychiatrySão Paulo SP ,Brazil

关键词: cytokines;    genetic markers;    mental disorder;    polymorphism;    citocinas;    marcadores genéticos;    transtorno mental;    polimorfismo;   

DOI  :  10.1590/S0004-282X2012000200003

来源: SciELO

【 摘 要 】

Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.

【 授权许可】

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