Meningeal carcinomatosis in solid tumors

Arquivos de Neuro-Psiquiatria

Sandro José Martins¹  Carla Rameri Alexandre Silva De Azevedo²  Ludmilla Thomé Domingos Chinen¹  Marcelo Rocha Sousa Cruz¹  Marcos Aurélio Peterlevitz¹  Daniel Luiz Gimenes¹ 

[1],Instituto de Medicina Integral de Pernambuco Department of Medical Oncology Recife PE ,Brazil

关键词: meningeal carcinomatosis;    cerebrospinal fluid;    meninges;    chemotherapy;    metastases;    carcinomatose meníngea;    líquido cefalorraquidiano;    meninges;    quimioterapia;    metástase;   

DOI  :  10.1590/S0004-282X2011000700024

来源: SciELO

【 摘 要 】

The involvement of the leptomeninges by metastatic tumors can be observed in solid tumors, in which case it is termed meningeal carcinomatosis (MC), and in lymphoproliferative malignant disease. It is more common in breast and lung cancer, as well as melanoma, with adenocarcinoma being the most frequent histological type. MC is usually a late event, with disseminated and progressive disease already present and, it is characterized by multifocal neurological signs and symptoms. Diagnosis is based on the evaluation of clinical presentation, cerebrospinal fluid and neuroimaging studies. The better systemic disease control is observed with new therapeutic agents, and the development of neuroimaging methods is responsible for the increasing incidence of such metastatic evolution. Intrathecal chemotherapy is generally the treatment of choice, although frequently palliative. Prognosis is guarded, although a higher performance status may indicate a subgroup of patients with a more favorable outcome.

【 授权许可】

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