Sudden death in a child with epilepsy: potential cerebellar mechanisms?

Arquivos de Neuro-Psiquiatria

Fulvio A. Scorza¹  Vera C. Terra²  Ricardo M. Arida¹  Américo C. Sakamoto²  Ronald M. Harper² 

[1] ,Universidade Federal de São PauloSão Paulo SP ,Brazil

关键词: SUDEP;    epilepsy;    cerebellum;    respiratory mechanisms;    seizures;    SUDEP;    epilepsia;    cerebelo;    mecanismos respiratórios;    crises;   

DOI  :  10.1590/S0004-282X2011000500024

来源: SciELO

【 摘 要 】

Epilepsy is the most common neurological disorder in humans. People with epilepsy are more likely to die prematurely than those without epilepsy, with the most common epilepsy-related category of death being sudden unexpected death in epilepsy (SUDEP). The central mechanisms underlying the fatal process remain unclear, but cardiac and respiratory mechanisms appear to be involved. Recently, cerebellar, thalamic, basal ganglia and limbic brain structures have been shown to be implicated in respiratory and cardiac rate regulation. We discuss here the potential mechanisms underlying the fatal process, with a description of cerebellar actions likely failing in that SUDEP process.

【 授权许可】

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