Primary progressive aphasia patients evaluated using diffusion tensor imaging and voxel based volumetry-preliminary results

Arquivos de Neuro-Psiquiatria

Fábio Pascotto De Oliveira²  Jaderson Costa Da Costa¹  Sabine Possa Marroni¹  Ana Maria Marques Da Silva²  Sthefanie Hansen Barreiro¹  Fábio Kunihiro Maeda¹  Mirna Wetters Portuguez¹ 

[1] ,HUSMSanta Maria RS ,Brazil

关键词: anomia;    primary progressive aphasia;    DTI;    tractography;    arcuate fasciculus;    language;    anomia;    afasia primária progressiva;    DTI;    tratografia;    volume cerebral;    fascículo arqueado;    linguagem;   

DOI  :  10.1590/S0004-282X2011000400007

来源: SciELO

【 摘 要 】

There are individuals who have a progressive language deficit without presenting cognitive deficits in other areas. One of the diseases related to this presentation is primary progressive aphasia (PPA). OBJECTIVE: Identify by means of diffusion tensor imaging (DTI) and measurements of cortical volume, brain areas that lead to dysphasia when presenting signs of impaired connectivity or reduced volume. METHOD: Four patients with PPA were evaluated using DTI, and measurements of cortical volumes in temporal areas. These patients were compared with two normal volunteers. RESULTS: There is a trend to a difference in the number and volume of related fibers between control group and patients with PPA. Comparing cortical volumes in temporal areas between groups yielded a trend to a smaller volume in PPA patients. CONCLUSION: Patients with PPA have a trend to impairment in cortical and subcortical levels regarding relevant areas.

【 授权许可】

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