The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats

Arquivos de Neuro-Psiquiatria

L D B Oliveira²  R W D Oliveira²  H A Futuro Neto¹  E M Nakamura-palacios² 

[1] ,Universidade Federal do Espírito Santo Centro de Ciências da Saúde Departamento de Ciências FisiológicasVitória ES ,Brazil

关键词: magnesium sulfate;    seizures;    experimental models;    PTZ;    rats;    sulfato de magnésio;    crises epilépticas;    modelos experimentais;    PTZ;    ratos;   

DOI  :  10.1590/S0004-282X2011000300016

来源: SciELO

【 摘 要 】

Magnesium sulfate (MgSO4) has been used to prevent seizures in eclampsia. This study examined the central effects of MgSO4 on different types of pentylenetetrazole (PTZ)-induced seizures. Male Wistar rats were submitted to intracerebroventricular (ICV) administration of MgSO4 at different doses followed by intraperitoneal administration of PTZ. The latency to the onset of the first seizure induced by PTZ was significantly increased by ICV administration of MgSO4 at a dose of 100 µg compared to the control treatment. In addition, the total period during which animals presented with seizures was significantly reduced at this dose of MgSO4. Furthermore, the latency to the onset of the first partial complex seizure was significantly increased by the lowest dose of MgSO4. However, a high dose of MgSO4 had no effect or even potentiated the effect of PTZ. These results suggest that, depending on the dose, MgSO4 may be important in prevention of epileptic seizures.

【 授权许可】

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