Restless legs syndrome and multiple sclerosis: a Brazilian multicenter study and meta-analysis of the literature

Arquivos de Neuro-Psiquiatria

Yára Dadalti Fragoso²  Alessandro Finkelsztejn¹  Sidney Gomes¹  Damacio Ramon Kaimen Maciel¹  Celso Luis S. Oliveira²  Josiane Lopes¹  Rafael A. Cristovam¹ 

[1] ,UNIMES Medical School Department of Neurology

关键词: multiple sclerosis;    restless legs syndrome;    meta-analysis;    esclerose múltipla;    síndrome das pernas inquietas;    metanálise;   

DOI  :  10.1590/S0004-282X2011000200007

来源: SciELO

【 摘 要 】

OBJECTIVE: The increased prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) has recently been the subject of a few papers. The present study investigated the prevalence of RLS symptoms in MS patients and in controls in four Brazilian cities. Additionally, a systematic review and meta-analysis of the literature was carried out on the subject of RLS-MS. METHOD: MS patients and controls were investigated regarding the presence of the four typical symptoms of RLS. A questionnaire assessing RLS severity was also used for patients and controls presenting the four RLS symptoms criteria. The systematic review and meta-analysis on the subject were carried out according to the strict international criteria. RESULTS: In the present report, the RLS-MS association was confirmed as being more than fortuitous in Brazilian MS patients, in a multicenter case-control study. MS patients also presented RLS symptoms of greater severity than did the control population. A systematic review and meta-analysis of the literature showed that MS patients had a fourfold higher chance of presenting RLS than did the controls. CONCLUSION: Although underlying mechanisms to explain the association RLS-MS are still a matter of discussion, there is a clear association of these two neurological conditions.

【 授权许可】

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