Study of the profile of the neurotrophin BDNF in new leprosy cases before, during and after multidrug therapy

Arquivos de Neuro-Psiquiatria

Rosane Dias Costa²  Vanessa Amaral Mendonça¹  Rachel Adriana Penido¹  Sandra Lyon¹  Ana Maria Duarte Dias Costa¹  Marina Dias Costa²  Fábio De Souza Terra¹  Thales Lage Bretas¹  Carlos Maurício De Figueiredo Antunes²  Antônio Lúcio Teixeira¹ 

[1] ,Santa Casa de Misericórdia of Belo HorizonteBelo Horizonte MG ,Brazil

关键词: leprosy;    BDNF;    peripheral neuropathy;    biomarker;    follow-up;    hanseníase;    BDNF;    neuropatia periférica;    biomarcador;    seguimento;   

DOI  :  10.1590/S0004-282X2011000100019

来源: SciELO

【 摘 要 】

Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in the survival of neurons and growth and differentiation of dendrites and axons. The purpose of the present study was to evaluate plasma levels of BDNF of leprosy patients at different stages of multidrug therapy (MDT) in comparison with non-infected individuals. Plasma levels of BDNF were measured by ELISA in 30 healthy controls and 37 leprosy patients at diagnosis, during and after MDT. Plasma levels of BDNF tended to be higher in control subjects in comparison with leprosy patients, but this difference does not reach statistical significance. Interestingly, BDNF levels changed following MDT, achieving statistical difference only at the 2nd dose of MDT. These results indicate that BDNF may not be a surrogate marker of leprosy infection and/or related neuropathy. Further research is needed to investigate the meaning of BDNF level changes following leprosy treatment.

【 授权许可】

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