PRAME gene expression profile in medulloblastoma

Arquivos de Neuro-Psiquiatria

Tânia Maria Vulcani-freitas²  Nasjla Saba-silva²  Andréa Cappellano²  Sérgio Cavalheiro¹  Sílvia Regina Caminada De Toledo² 

[1] ,Federal University of São Paulo University of São Paulo Pediatric Oncology Institute (GRAACC) São Paulo SP ,Brazil

关键词: PRAME;    gene expression;    medulloblastoma;    immunotherapy;    PRAME;    expressão gênica;    meduloblastoma;    imunoterapia;   

DOI  :  10.1590/S0004-282X2011000100003

来源: SciELO

【 摘 要 】

Medulloblastoma is the most common malignant tumors of central nervous system in the childhood. The treatment is severe, harmful and, thus, has a dismal prognosis. As PRAME is present in various cancers, including meduloblastoma, and has limited expression in normal tissues, this antigen can be an ideal vaccine target for tumor immunotherapy. In order to find a potential molecular target, we investigated PRAME expression in medulloblastoma fragments and we compare the results with the clinical features of each patient. Analysis of gene expression was performed by real-time quantitative PCR from 37 tumor samples. The Mann-Whitney test was used to analysis the relationship between gene expression and clinical characteristics. Kaplan-Meier curves were used to evaluate survival. PRAME was overexpressed in 84% samples. But no statistical association was found between clinical features and PRAME overexpression. Despite that PRAME gene could be a strong candidate for immunotherapy since it is highly expressed in medulloblastomas.

【 授权许可】

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