Progressive supranuclear palsy: new concepts

Arquivos de Neuro-Psiquiatria

Orlando Graziani Povoas Barsottini¹  André Carvalho Felício¹  Camila Catherine Henriques De Aquino¹  José Luiz Pedroso¹ 

[1] ,Federal University of São Paulo Department of Neurology and Neurosurgery São Paulo SP ,Brazil

关键词: progressive supranuclear palsy;    atypical parkinsonism;    tauopathy;    paralisia supranuclear progressiva;    parkinsonismo atípico;    taupatias;   

DOI  :  10.1590/S0004-282X2010000600020

来源: SciELO

【 摘 要 】

Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach.

【 授权许可】

CC BY   
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