Microsurgical clipping in forty patients with unruptured anterior cerebral circulation aneurysms: an investigation into cognitive outcome

Arquivos de Neuro-Psiquiatria

Arthur A Pereira-filho²  Adriana G Pereira²  Mário B Faria¹  Leonardo C.s Lima¹  Mirna W Portuguez²  Jorge L Kraemer¹ 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul Neurosciences Post-Graduation Program School of MedicinePorto Alegre RS ,Brazil

关键词: cerebral aneurysm;    surgical clipping;    cognitive impairment;    mini mental state examination;    aneurisma cerebral;    clipagem cirúrgica;    déficit cognitivo;    mini exame do estado mental;   

DOI  :  10.1590/S0004-282X2010000500018

来源: SciELO

【 摘 要 】

OBJECTIVE: It is a consensus that most unruptured intracranial aneurysms (UIA) can be treated with acceptably low morbidity. However, some studies recently reported postoperative cognitive impairment, suggesting that it could be attributable to surgical damage. Our goal is to evaluate cognitive function before and after microsurgical clipping in patients with UIA. METHOD: A consecutive series of 40 patients who underwent microsurgical clipping for UIA were studied. The cognitive assessment (Mini Mental State Examination, MMSE) was performed immediately before and at least one month after surgery. Paired Student's "t" test and analysis of variance (ANOVA) were used for statistical purposes. RESULTS: The mean MMSE score in the preoperative analysis was 28.12 (SD, 1.34). In the postoperative period the mean MMSE score was 28.40 (SD, 1.46). Paired Student's "t" test was applied to the scores and no significant difference was found (p=0.315). ANOVA did not find independent associations between MMSE scores and age, hypertension, smoking, dyslipidemia, education, aneurysm location, number, laterality or size. CONCLUSION: The present study suggests that microsurgical clipping for UIA does not result in major cognitive dysfunction as determined by the MMSE

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