Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis

Arquivos de Neuro-Psiquiatria

Murilo Gimenes Rodrigues²  Jaime Lin²  Marcelo Rodrigues Masruha²  Luiz Celso Pereira Vilanova²  Thais Soares Cianciarullo Minett¹ 

[1] ,Federal University of São Paulo Department of Neurology and Neurosurgery São Paulo SP ,Brazil

关键词: tuberculosis;    meningitis;    central nervous system;    prognosis;    child;    tuberculose;    meningite;    sistema nervoso central;    prognóstico;    crianças;   

DOI  :  10.1590/S0004-282X2010000500015

来源: SciELO

【 摘 要 】

OBJECTIVE: To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings. METHOD: The clinical records of all in-patients diagnosed with neurotuberculosis from 1982 to 2005 were evaluated retrospectively. The following prognostic parameters were examined: gender, age, close contact with a tuberculosis-infected individual, vaccination for bacillus Calmette-Guérin, purified protein derivative (PPD) of tuberculin results, concomitant miliary tuberculosis, seizures, CSF results, and hydrocephalus. RESULTS: One hundred forty-one patients diagnosed with neurotuberculosis were included. Seventeen percent of the cases resulted in death. The factors that were correlated with a negative outcome included lack of contact with a tuberculosis-infected individual, negative PPD reaction, coma, and longer hospitalisation time. A multiple logistic regression analysis was performed to identify which of these factors most often resulted in death. CONCLUSION: Coma at diagnosis, lack of tuberculosis contact, and a non-reactive PPD were the most important predictors of fatality in patients with neurotuberculosis

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