Arquivos de Neuro-Psiquiatria | |
Prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis | |
Murilo Gimenes Rodrigues2  Jaime Lin2  Marcelo Rodrigues Masruha2  Luiz Celso Pereira Vilanova2  Thais Soares Cianciarullo Minett1  | |
[1] ,Federal University of São Paulo Department of Neurology and Neurosurgery São Paulo SP ,Brazil | |
关键词: tuberculosis; meningitis; central nervous system; prognosis; child; tuberculose; meningite; sistema nervoso central; prognóstico; crianças; | |
DOI : 10.1590/S0004-282X2010000500015 | |
来源: SciELO | |
【 摘 要 】
OBJECTIVE: To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings. METHOD: The clinical records of all in-patients diagnosed with neurotuberculosis from 1982 to 2005 were evaluated retrospectively. The following prognostic parameters were examined: gender, age, close contact with a tuberculosis-infected individual, vaccination for bacillus Calmette-Guérin, purified protein derivative (PPD) of tuberculin results, concomitant miliary tuberculosis, seizures, CSF results, and hydrocephalus. RESULTS: One hundred forty-one patients diagnosed with neurotuberculosis were included. Seventeen percent of the cases resulted in death. The factors that were correlated with a negative outcome included lack of contact with a tuberculosis-infected individual, negative PPD reaction, coma, and longer hospitalisation time. A multiple logistic regression analysis was performed to identify which of these factors most often resulted in death. CONCLUSION: Coma at diagnosis, lack of tuberculosis contact, and a non-reactive PPD were the most important predictors of fatality in patients with neurotuberculosis
【 授权许可】
CC BY
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RO202005130010814ZK.pdf | 141KB | download |