Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis

Arquivos de Neuro-Psiquiatria

Fabio Augusto Bronzi Guimarães²  Érika Arantes De Oliveira-cardoso²  Ana Paula Mastropietro²  Júlio César Voltarelli¹  Manoel Antônio Dos Santos² 

[1],University of São Paulo Faculty of Philosophy, Sciences and Letters of Ribeirão Preto Post-graduation Program in PsychologyRibeirão Preto SP ,Brazil

关键词: quality of life;    multiple sclerosis;    bone marrow transplantation;    qualidade de vida;    esclerose múltipla;    transplante de medula óssea;   

DOI  :  10.1590/S0004-282X2010000400009

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.

【 授权许可】

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