Brain hypoperfusion in adolescents dependent of multiple drugs

Arquivos de Neuro-Psiquiatria

Elba Cristina Sá De Camargo Etchebehere²  Felipe Martins Oliveira²  Bárbara Juarez Amorim²  Saulo Monte Serrat¹  Edwaldo Eduardo Camargo² 

[1] ,Campinas State University School of Medical Sciences Department of RadiologyCampinas SP ,Brazil

关键词: computed tomography;    emission-computed;    single-photon;    substance-related disorders;    drug abuse;    drug addiction;    substance abuse;    substance dependence drug abuse;    tomografia computadorizada de emissão de fóton único;    transtornos relacionados ao uso de substâncias;    abuso de drogas;    abuso de substâncias;    drogadicção;    dependência por abuso de drogas;   

DOI  :  10.1590/S0004-282X2010000200002

来源: SciELO

【 摘 要 】

Brain SPECT imaging (BSI) with statistical parametric mapping (SPM) offers a clear and accurate vision of perfusion changes. OBJECTIVE: To study brain perfusion abnormalities in adolescents' dependent of multiple drugs. METHOD: Sixteen male patients (15.1±2.1 years) were submitted to 99mTc-HMPAO BSI with SPM. RESULTS: Cortical hypoperfusion occurred in 7/16 patients (44%). There was a significant inverse correlation between the number of hypoperfused regions and the patient's age (p= -0.6737; p=0.004) and with the age when the drug dependence began (p= -0.5616; p=0.023). There was also a tendency towards an inverse correlation between regions of hypoperfusion and the duration of the drug dependence. CONCLUSION: BSI with SPM can help detect hypoperfusion in adolescents dependent on multiple drugs. The younger the patients, the more regions of hypoperfusion are noted. Probably, the neuronal plasticity has an important role in this phenomenon because the highest neural activity occurs in childhood.

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