期刊论文详细信息
Arquivos de Neuro-Psiquiatria
Mechanical hypernociception in experimental autoimmune encephalomyelitis
David Henrique Rodrigues1  Daniela Sachs1  Antonio Lucio Teixeira1 
[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Biológicas Departamento de Bioquímica e ImunologiaBelo Horizonte MG ,Brasil
关键词: multiple sclerosis;    experimental autoimmune encephalomyelitis;    hyperalgesia;    mechanical hypernociception;    esclerose múltipla;    encefalomielite autoimune experimental;    hiperalgesia;    hipernocicepção mecânica;   
DOI  :  10.1590/S0004-282X2009000100019
来源: SciELO
PDF
【 摘 要 】

BACKGROUND: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. OBJECTIVE: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. METHOD: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the von Frey filaments method. A clinical scale ranging from 0 to 15 was used to assess motor impairment. RESULTS: Clinical evidence of disease started at day 10 and peaked at day 14 after immunization. Thereafter, there was no worsening of symptoms until day 26. The EAE-induced mice presented reduced pressure threshold at days 7th and 10th after immunization and before the onset of clinical motor signs. CONCLUSION : The hypernociception found validates MOG35-55 EAE as a model for the study of pain in multiple sclerosis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

【 预 览 】
附件列表
Files Size Format View
RO202005130010407ZK.pdf 300KB PDF download
  文献评价指标  
  下载次数:4次 浏览次数:4次