Botulinum toxin type A in the treatment of lower-limb spasticity in children with cerebral palsy

Arquivos de Neuro-Psiquiatria

Carlos Henrique F. Camargo²  Hélio A.g. Teive¹  Marise Zonta¹  Gilmar C. Silva¹  Marcelo R. Oliveira²  Maurício M. Roriz²  Ivar V. Brandi²  Nilson Becker²  Rosana Hermínia Scola¹  Lineu César Werneck¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Department of Clinical MedicineCuritiba PR ,Brazil

关键词: cerebral palsy;    botulinum toxin;    spasticity;    paralisia cerebral;    espasticidade;    toxina botulínica;   

DOI  :  10.1590/S0004-282X2009000100016

来源: SciELO

【 摘 要 】

We evaluated the safety and effectiveness of botulinum toxin A (BoNT/A) in the treatment of spasticity in 20 children with spastic diplegic cerebral palsy (CP). All the patients received injections in the gastrocnemius and soleus, and 15 received injections in the adductors. The total dose varied from 70 to 140 U (99.75±16.26 U), or 7.45±2.06 U/kg per patient. The treatment improved the patients' walking and gait pattern significantly. There was also a significant alteration in the heel-ground distance and increased motion of the ankle joint. These structural changes in the feet were sustained until the end of the follow-up, although the same was not observed for the functional parameters. Three patients complained of weakness in the lower limbs. In conclusion, BoNT/A is safe and effective when used in a single session of injections and produces a sustained structural modification of the lower limbs. However, functional changes are temporary and are only observed during the peak effect of the drug.

【 授权许可】

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