Pediatric multiple sclerosis: analysis of clinical and epidemiological aspects according to National MS Society Consensus 2007

Arquivos de Neuro-Psiquiatria

Maria Lúcia Brito Ferreira²  Maria Íris Morais Machado²  Maria José Guedes Dantas¹  Álvaro José Porto Moreira²  Adélia Maria De Miranda Henriques Souza¹ 

[1] ,Hospital da Restauração Centre for Attention to Patients with Demyelinating Diseases Neurology DepartmentRecife PE ,Brazil

关键词: multiple sclerosis;    classification;    epidemiology;    diagnose techniques and procedure;    esclerose múltipla;    classificação;    epidemiologia;    técnicas de diagnóstico e procedimento;   

DOI  :  10.1590/S0004-282X2008000500011

来源: SciELO

【 摘 要 】

OBJECTIVE: To describe the epidemiological and clinical characteristics of child/adolescence multiple sclerosis (MS). METHOD: According to a descriptive, cohort study, with comparison of groups, data of 31 cases of child/adolescent MS, diagnosed at State Reference Center for Demyelinating Diseases - Hospital da Restauração, Recife, Pernambuco, Brazil, from 1987 to July 2007, were analyzed. The variables were: sex, initial symptoms, time for diagnosis, time of disease onset (early childhood, later childhood and adolescence), time of follow-up, number of relapses, relapses index and disability. Using SPSS software, version 13.0, t Student and Mann-Whitney tests were performed, with significance level of 0.05. RESULTS: There were 3 (9.7%) cases of early childhood MS, 9 (29%), of late childhood MS, and 19 (61.3%), of adolescence MS. The general sex rate female: male was 1.8:1, varying according to age of onset. The predominant deficits were motor (12; 38.7%) and brainstem/cerebellum (7; 22.5%) especially on subsequent relapses of relapsing/remitting form. Time for diagnosis and average relapses index were higher in early childhood than in adolescence class (p=0.049 and p=0.028, respectively). Disability was higher for primary and secondary MS, as well as for early childhood. CONCLUSION: Early childhood MS presents proper and different characteristics from adults, consisting in a difficult diagnosis that demands aid of expert neurologist on MS.

【 授权许可】

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