Benefit with methylprednisolone in continuous pulsetherapy in progressive primary form of multiple sclerosis: study of 11 cases in 11 years

Arquivos de Neuro-Psiquiatria

Edmar A.s. De Araújo¹  Marcos R. Gomes De Freitas¹ 

[1] ,Universidade Federal Fluminense Hospital Universitário Antonio Pedro Neurological ServiceNiterói RJ ,Brazil

关键词: progressive primary form;    multiple sclerosis;    methylprednisolone;    forma primária progressiva;    esclerose múltipla;    metilprednisolona;   

DOI  :  10.1590/S0004-282X2008000300013

来源: SciELO

【 摘 要 】

Primary progressive multiple sclerosis (PPMS) is defined clinically with a progressive course from onset. There is no approved treatment for the PPMS. Methylprednisolone IV (MP) hastens the recovery from MS relapses. We studied 11 patients that met the MacDonald's diagnostic criteria for PPMS. The dose of MP was 30 mg/kg in 250 mL of glucose solution in three consecutive days during the first week, two doses during the second and one dose in the third week. One weekly session for eight consecutive weeks was given. After, a once-a week/eight-week interval was maintained. The medium EDSS before treatment was 6.2, and after 11.2 years of treatment, the EDSS was 4.9. Although we studied a small sample of PPMS we may conclude that therapy with IVMP prevents clinical worsening of MS in the majority of patients with improvement in EDSS scores.

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