Oligosymptomatic dengue infection: a potential cause of Guillain Barré syndrome

Arquivos de Neuro-Psiquiatria

Cristiane Nascimento Soares²  Mauro Cabral-castro¹  Celina Oliveira¹  Luis Claudio Faria¹  José Mauro Peralta¹  Marcos Raimundo Gomes De Freitas²  Marzia Puccioni-sohler¹ 

[1] ,Universidade Federal Fluminense Hospital Universitário Antônio Pedro Neurology ServiceNiterói RJ ,Brazil

关键词: dengue;    polyradiculoneuritis;    radiculoneuropathy;    CSF;    Guillain Barré syndrome;    dengue;    polirradiculoneurite;    radiculoneuropatia;    líquido cefalorraqueano e síndrome de Guillain Barré;   

DOI  :  10.1590/S0004-282X2008000200018

来源: SciELO

【 摘 要 】

BACKGROUND: Dengue infection may cause neurological manifestations such as encephalitis, myelitis, mononeuropathies, acute disseminated encephalomyelitis, and Guillain Barré syndrome (GBS). In endemic regions, the infection course can be oligosymptomatic making difficult the diagnosis of the neurological picture associated with dengue infection. OBJECTIVE: To report dengue infection and GBS association, even in oligosymptomatic cases of this infection. METHOD: During the dengue epidemic in Rio de Janeiro city we looked for GBS cases, testing IgM antibodies for dengue and dengue polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF) and serum. RESULTS: We report seven cases (46.6%), presenting dengue positive IgM in serum but with poor or without clinical symptoms of the previous infection. Two of them had also positive IgM antibodies in CSF. CONCLUSION: These data show that search for dengue infection should be a routine in GBS cases living in endemic areas.

【 授权许可】

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