Neurological outcome of newborns with neonatal seizures: a cohort study in a tertiary university hospital

Arquivos de Neuro-Psiquiatria

Magda Lahorgue Nunes²  Maurer Pereira Martins¹  Bianca Menke Barea¹  Ricardo C. Wainberg¹  Jaderson Costa Da Costa¹ 

[1] ,Pontifícia Universidade Católica do Rio Grande do Sul School of Medicine Hospital São LucasPorto Alegre RS ,Brazil

关键词: neonatal seizures;    follow up;    epilepsy;    neonatal EEG;    preterm newborn;    convulsões neonatais;    seguimento;    epilepsia;    EEG neonatal EEG;    prematuridade;   

DOI  :  10.1590/S0004-282X2008000200005

来源: SciELO

【 摘 要 】

OBJECTIVE: To describe the neurological outcome of newborns with seizures. METHOD: Cohort study with newborns prospectively followed. Perinatal characteristics and etiological screening were related to outcome in a regression model. RESULTS: During the study 3659 newborns were admitted and 2.7% were diagnosed as having seizures. Hypoxic ischemic encephalopathy (51%) was the etiology more frequently associated to seizures and also to postneonatal epilepsy (53%). In the follow up 25 died during the acute neonatal illness and 9 during the first years of life, 19 were diagnosed as having post neonatal epilepsy, 35 had developmental delay and 11 an association among this two comorbidities. A significant association between abnormal postnatal EEG and neuroimaging to developmental delay (p=0.014, p=0.026) was observed. The group of newborns that had seizures presented an increased risk of developing epilepsy compared to newborns from the same cohort without seizures (19.3/100 vs. 1.8/100, p<0.001). CONCLUSION: In this study neonatal seizures predominated in term newborns with perinatal asphyxia an elevated perinatal mortality and post neonatal morbidity was observed.The follow up showed an increased risk for developing postnatal epilepsy and developmental delay.

【 授权许可】

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